Not exactly. Once fat cells are removed from the body in any capacity, whether from Vanquish ME or CoolSculpting for example, they are gone for good. Diet and exercise simply shrink fat cells, but Vanquish ME actually removes them from the body. However, it is still possible to gain weight after Vanquish ME because other, nearby fat cells can increase in size. A healthy diet and exercise are important at all times, including after Vanquish ME.